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Using Downhill Marathons to Qualify for Boston
(answer continued...) 

So it’s not surprising that Boston ONLY requires that a qualifying time be accomplished on a course that has been Certified  by the country’s national governing body (e.g., Athletics Canada, USATF) in which the race is held.
 
So, it's carte blance folks as any certified downhill course is good to go. (Cue the late and great Tom Petty’s Free Falling) 
 
Consequently, and to put it in gambler's terms, some runners are seeing the St. George event  and raising it the Revel Mount Charleston Marathon in Las Vegas.
 

Why? Because Revel’s start is at 7915 ft.(= 2412 m.), and the finish is at  2725 ft. (= 830.6 m.) for a  whopping  average decline of 37.5 m/km. And the overall average slope is about minus 3.75%. 

 
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For those living in Toronto, Ontario, Revel's slope is similar to the slope on Yonge St., between Hwy 401 and York Mills. 
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Yonge St. looking south from Hwy 401

​So What's the Advantage?
 
A 1997 University of New Mexico study  aimed to quantify the advantage  gained with various negative slopes from 0, -1.8, -3.6, and -5.4%. And the investigators concluded that for a given speed, running at even a modest negative grade can significantly decrease the oxygen consumption (VO2) level for the same pace
 
In fact , they came up with a regression equation which predicts, for example, that  a 3:30 (=8:00/mile)  marathoner running at sea level  would run closer to 6:50 /min.  if running down  a Revel-like slope of 3.75 % slope  An advantage of about  70  seconds!

And all the runners shout Hallelujah !  
 
 
BUT Not So Fast – What About Altitude?
 
Yes, what about atlitude. Revel’s Start, at 2412 m., is higher than Mexico City (2250 m.), which is renowned for the negative impact it had on the distance runners at the 1968 Olympics, most famously, multi-world recorder holder, Ron Clarke. 
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In fact, a Norwegian group conducted a study on the impact of altitude on oxygen consumption capability. Their results were  published in the European Journal of Applied Physiology in 2006. 

They measured endurance-trained athletes at simulated altitudes of up to 2,800 m., finding that  Maximum Oxygen Intake (VO2max) decreased, on average,  6.3% for every 1,000 m. increase in altitude
 
This relationship is recognized by the NCAA (National Collegiate Athletic Association), who has developed a converter  for  performances at altitude (you can download it from HERE). The image below shows an example for converting a sea level 8:00/mile pace to what its equivalent is in Alamosa,  Colorado (alt. = 7,544 ft.) . It shows that an 8:00/mile  pace is slowed to about 8:30/mile – about 30 seconds. ​
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But Revel is even higher than Alamosa, so I would estimate that our 8:00/mile marathoner  would be slowed to running 8:40 per mile if running on a flat grade, especially a non-acclimatized runner.

But as we saw earlier, Revel's downhill slope of  3.75 slope provides about  70 seconds gain in speed.


 The Bottom Line for Revel

So where does this leave us? Well, it's certainly clear that the downhill advantage outweighs the negative impact of altitude.  I estimate our 3:30 marathoner is going to be able to run about 30 seconds per mile faster than at sea level just after the start . And that advantage should continuously increase as the impact of altitude becomes less and less going down the mountain...

Some Other Considerations

Now before  you decide on this option be aware that there are several potential  health issues associated with High Altitude Sickness, including 
headaches, suppressed hunger, dizziness, insomnia  fatigue and nausea, which could lead to vomiting. Nice.

So, if you're a sea level inhabitant, some running at the race's altitude in advance would be ideal since, you're not likely going to have time to acclimatize. 

And then there's the issue of the much greater  impact on the leg muscles and joints which, in an ill-prepared runner, can result in severe tightening of the thigh muscles well before the finish line. This is the same concern as for  Boston. So its extremely important that you incorporate a substantial amount of downhill running in your regimen.

Read the Reviews

No question a well prepared should run substantially faster at Revel. But I suggest you read reviews by bloggers and at website posting boards to get a heads up - here are a few links to check out: (1),  (2),  (3). 

And One I Don't Recommend for Qualifying...

Now, please no one ask me about the Mt. Everest Marathon which
 is listed in the Guinness Book of Records as the highest marathon in the world. The start is at 5184m (17,000 feet), and the finish is at 3446m (11,300 feet). 

Can you imagine you've kept your Everest quest a secret and your spouse walks in on you while you're packing and asks, "what's the parachute for honey?...
and what's with the yodeling?" 
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